Choose from 500 different sets of chemistry body fluids flashcards on quizlet. The asssociation of clinical biochemists in ireland the biochemistry of body fluids version 1. Current knowledge in the field is reflected in the next two subcourses you are about to study. Specifically, that subcourse focused on instrumentation and the principles of their use as well as a general discussion of chemistry. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The biochemistry of body fluids association of clinical.
Body fluids from nonblood or urine sources present a difficult challenge for clinical laboratories. Content provider clinical and laboratory standards institute clsi add to alert pdf add to alert. The definition of fluid, as used in chemistry, chemical engineering, and physics, plus examples. The added colour has helped to produce a very readable book, with well laid out text and useful diagrams.
Clinical chemistry uses many different methodologies, manual and fully automated. Body fluids present a challenge for clinical chemistry analysis due to their wide variety of sources and possible matrices 1 2 34. In the clinical lab, the most common body fluids encountered are cerebral spinal fluid csf, amniotic fluid, the serous fluids pleural, peritoneal ascites, and pericardial, and synovial fluid. Antonio javier blasco, alberto escarpa, in comprehensive analytical chemistry, 2005. Practica encompass the clinical areas of hematologycoagulation, urinalysis, clinical chemistry, microbiology, clinical immunology, and immunohematology program director. Nov 07, 2014 summary body fluids are diverse, with variation in physical appearance, properties, cell types, and cell counts. Clinical chemistry 6th edition bishop internet archive.
The information was assimilated from an extensive literature search of studies e. Subcourses md0861 and md0863, clinical chemistry i and ii, address areas of particular importance in clinical chemistry and toxicology i dont. Mike was awarded the uk healthcare scientist of the year award in november 2008 by the uk chief scientific officer, professor sue hill, and was the 2011 winner of the efccroche european scientific award for laboratory medicine. Clinical and laboratory standards institute, 950 west valley road, suite 2500, wayne, pennsylvania 19087 usa, 2007.
The clinical and laboratory standards institute clsi is in the process of finalizing the second edition of the guideline document, analysis of body fluids in clinical chemistry 1. Summary body fluids are diverse, with variation in physical appearance, properties, cell types, and cell counts. Lednev associate professor department of chemistry university at albany, suny, 1400 washington ave albany, ny 12222. Tlc has the advantage over other methods in that it can screen for many drugs simultaneously, with a relatively high sensitivity, and can handle several samples per plate. Dec 01, 2016 the clinical and laboratory standards institute clsi is in the process of finalizing the second edition of the guideline document, analysis of body fluids in clinical chemistry 1.
Body fluids forensic serology introduction prior to the development of dna typing, forensic serology was the primary technique of crime labs. Clsi c49a analysis of body fluids in clinical chemistry. Analysis of fluids, such as urine, semen, or sweat. Urinalysis and body fluids by susan king strasinger. Body fluid analysis is a broad term and refers to tests that may be performed on a sample of body fluid, besides blood. Application of raman spectroscopy for an easytouse, onfield, rapid, nondestructive, confirmatory identification of body fluids 2009 dnbxk186 final technical report to the department of justice february 29, 2012 igor k. Semiauto chemistry analyzer users manual saca19100 please read this manual carefully before operation 3, hagavish st. Biochemistry module body water, osmolarity and ionic composition of body fluids biochemistry 198 notes table 14. Documents sold on the ansi webstore are in electronic adobe acrobat pdf format, however some iso and iec standards are available from. It covers widely the curriculum needs of medical students as well as clinical scientists and other health care professionals. From the classroom to the lab, this text provides complete coverage of the latest advances in clinical chemistry. Clinical chemistry is the branch of laboratory medicine that focuses primarily on molecules. Fluids comprise a subset of the states of matter and include liquids, gases, and plasma.
Oct 01, 2015 despite the difficulties of offlabel body fluid testing, it remains a powerful clinical tool when used appropriately and the risks are recognized and reduced. Abnormal body fluids provide a readily accessible source of diagnostic information. Performance specifications of common chemistry analytes on. Md, phd, dsc department of laboratory medicine, faculty of. C49ed2 analysis of body fluids in clinical chemistry, 2nd.
These tests may use different kinds of body fluids such as whole blood. See section 6 for more detail about specific analytes. Medical laboratory sciences clinical practicum handbook. The clinical and laboratory standards institute consensus process, which is the mechanism for moving a document through. Urinalysis and body fluids, 6th edition laboratory. The clinical and laboratory standards institute clsi is a notforprofit membership organization.
A change in concentration or composition of a particular biochemical constituent in body fluids is used as an indicator of a physiological or pathological condition. Pdf raman and autofluorescence analysis of human body fluids. Clsi c49 analysis of body fluids in clinical chemistry. The purpose and practicality of body fluid testing and. Body fluids, defined as specimens other than plasma, serum, or urine. The format of each chapter is clear, concise, and easy to follow. Key concepts that apply to the entire test cycle, including preexamination, examination, and postexamination phases of body fluid testing, are discussed. Body chemistry analysis is a procedure in which we will take a urine and saliva sample from you and run specific lab work in order to find out what your body is lacking in, nutrient wise that is. Richard vandell, ms mtascpsc, sh contact numbers tel. These documents deal with the clinical utility of analyte measurements in the majority of fluid types. Learn chemistry body fluids with free interactive flashcards.
Clinical chemistry refers to the biochemical analysis of body fluids. Body fluid analysis, clinical chemistry, interference, hemolysis. Reprinted from lam cw, lai ck and chan yw 1998 clinical chemistry 44 2. Chemistry tests in body fluids effective march 1st, 2016, the providence regional core laboratory will measure the ph on body fluids when measuring albumin, amylase, ldh, and lipase. An additional complication is that most body fluids are. Henrys clinical diagnosis and management by laboratory methods. This well known textbook now appears in its 5th edition with an additional writer. Hematology, clinical chemistry, urinalysis, immunology, serology, histopathology, immunohematology and molecular biology and others. This book presents the important aspects of clinical chemistry in the made easy format for the senior clinical medical student. Indeed, the labonachip concept is intimately linked to this area of analytical chemistry. Combining metabolomics with clinical chemistry allows for powerful analyses of the human body. In clinical chemistry the interferences by bilirubin, hemoglobin, lipids, proteins and drugs are most frequently occurring.
Selectivity is property of a measuring system, used with a specified measurement procedure, whereby it provides measured quantity values for one or more measurands such. Urinalysis and body fluids, 6th edition laboratory medicine. Clinical and laboratory standards institute guideline c49analysis of body fluids. Application of raman spectroscopy for an easytouse, on. This update covers topics across the total testing process, equipping laboratories with stepbystep instructions to assess the analytical performance of assays. Bioanalytical and clinical analysis are of crucial significance around the world, and many of the unique possibilities of miniaturized systems are very important in this field. Clinical chemistry 6th edition bishop pdf epub info share 3 788. Cerebrospinal fluid analysis csf is the fluid surrounding the brain and spinal cord. This comprehensive, uptodate, readable text acts as a complete clinical chemistry course and professional reference, providing detailed, specific information on the principles of clinical chemistry in laboratory diagnosis as well as the pathophysiologic changes that occur in disease and affect testing outcomes. American proficiency institute 2018 2nd test event 2 cerebrospinal, peritoneal, pericardial, pleural, synovial, and amniotic fluids are nonstandard fluids frequently submitted to the laboratory for testing, a number of other fluids may be submitted as well. It is an applied form of biochemistry not to be confused with medicinal chemistry, which involves basic research for drug development. In addition to ensuring that the test performance characteristics are adequate for the intended use, laboratories also can improve patient safety by engaging with the clinical team to improve appropriate test utilization and result.
C49ed2 analysis of body fluids in clinical chemistry. Fundamentals of urine and body fluid analysis 9780323374798. In addition to ensuring that the test performance characteristics are adequate for the intended use, laboratories also can improve patient safety by engaging with the clinical team to improve appropriate test utilization. Clinical chemistry i introduction clinical chemistry is a very dynamic field of science.
Clinical chemistry, as one example of these subjects, is analyzed in detail to understand the thinking process. Known for its clear writing style, logical organization, and vivid fullcolor illustrations, this renowned text covers the fundamental principles of urine and body fluids that are frequently encountered in the clinical laboratory. I find the textbook urinalysis and body fluids to be well written and of excellent quality. Clinical and laboratory standards institute, 940 west valley road, suite 1400, wayne, pennsylvania 190871898 usa, 2007. Aug 12, 2019 the definition of fluid, as used in chemistry, chemical engineering, and physics, plus examples. This course provides a survey of organisms encountered in the clinical microbiology laboratory, and includes sterilization and disinfection techniques. Clinical analysis an overview sciencedirect topics. Describe the composition, formation and functions of selected body fluids.
The study of body fluids presents challenges to the laboratory. Each of these fluids exhibits unique biochemical profiles, reflecting the organ system they surround. Introduction to medical laboratory technology is a basic course that equips the student with the most essential knowledge and skill pertaining to medical laboratories such as. Principles of applied clinical chemistry chemical background. This guideline provides information for the medical laboratory for evaluating measurement procedures, as well as a strategy to characterize assay performance when applied to body fluid matrixes.
Clsi c49 analysis of body fluids in clinical chemistry 2nd edition. Clinical chemistry encompasses the study of the fundamental princi ples of chemistry as applied to an understanding of the functioning of the human organism in health and disease. This manual is the operating guidance of semiauto chemistry analyzer, which including the contents of instrument installation, daily test, quality control, and daily maintenance, etc. Clinica chimica acta 426 20 121126 have demonstrated that ph has a significant effect in the recovery of the analytes. The strengths of each chapter are the understandable learning objectives, key terms, case studies, clinical situations depicted, and technical tips. Fluid accumulation in the pleural, pericardial, and peritoneal cavities is known as a serous effusion. This website provides reference intervals andor interpretive guidance when testing for common and esoteric analytes in body fluids. Some do not have a dna typing facility owing to either a lack of resources or a lack of enough cases to warrant the investment.
The second part of the work is concerned with the clinical. This volume deals with the analyses of body fluids other than blood and urine. This subcourse, clinical chemistry ii md0863, will provide you. The clinician uses the information provided by body fluid analysis to formulate, in order of priority, a list of differential diagnoses and to follow the results of therapy. Significance of the body fluids in clinical medicine. The analysis of body fluids plays a critical role in the diagnosis and prognosis of a disease. Several simple chemical tests are used to detect and quantify different compounds in blood and urine, the most commonly tested. The information was assimilated from an extensive literature search of studies eg, metaanalysis, guidelines, and key textbooks related to the interpretation of body fluid testing. Clinical chemistry made easy, jeremy hughes, ashley jefferson, jonathan ashley jefferson, 2008, medical, 204 pages.
Evaluate body fluid specimens for acceptability based on labeling, appropriate volume, collection, handling and storage requirements. This guideline provides information for the medical laboratory for evaluating measurement procedures, as well as a strategy to characterize assay performance, when applied to body fluid matrixes. Department of health and human services public healthservice. The tests in a clinical chemistry laboratory measure concentrations of biologically important ions salts and minerals, small organic molecules and large macromolecules primarily proteins. Part one of the text includes content on laboratory techniques and practice, and part two provides detailed descriptions of how specific diseases affect the human body. In this reference, case studies and clinical situations analyze and explore the clinical significance of nonblood body fluids and are designed to aid students in developing the skills of problem solving and critical thinking that are essential in a clinical laboratory. It is for the clinical tests of body blood and the tests of all kinds of routine biochemical indexs of other body fluids. Clinical chemistry also known as chemical pathology, clinical biochemistry or medical biochemistry is the area of chemistry that is generally concerned with analysis of bodily fluids for diagnostic and therapeutic purposes.
Most labs still use basic serological testing procedures. If you are feeling tired all the time, anxious, depression has set in, headaches are persistent, or youre just not feeling 100%, you might be a. Analysis of body fluids in clinical chemistry clsi. Evaluate body fluid specimens to determine suitability for tests requested.